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Gamabufotalin has been shown to strongly inhibit cancer cell growth and inflammatory response, CS-6 inhibits angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways and CS-6 could be a potential candidate in angiogenesis-related disease therapy.
Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma(MM) cells, it may be as a promising therapeutic agent in the treatment of MM.
Gamabufotalin(CS-6), a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells, suggests that CS-6 exhibits potential use in the treatment of COX-2-mediated diseases such as lung cancer.
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The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: poisonous secretion of toads Bufo vulgaris formosus and Bufo bufo gargarizans, and toad poison Ch'an Su. Rhabdophis tigrinus
identification-method: Mass, NMR
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