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Germacrone

CAS: 6902-91-6

Ref. BP-BP0641

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Estimated delivery in United States, on Monday 15 Jun 2020

Product Information

Name:
Germacrone
Synonyms:
  • Germacrol (obsol;)
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

Germacrone has anti-tumor activity against liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. [3]
Germacrone moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM,and produces two oxidized metabolites and four glutathione conjugates. [2]
Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung, it could as a therapeutic agent alone or in combination with other agents for the treatment of influenza virus infection. [4]
Germacrone, a natural product isolated from Rhizoma curcuma, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. [1]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Geranium macrorrhizum, Curcuma wenyujin and Rhododendron adamsii
identification-method: Mass, NMR
type-of-compound: Sesquiterpenoids


Chemical properties

Molecular weight:
218.34
Formula:
C15H22O
Purity:
98%
Color/Form:
Cryst.

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