Ingenol Mebutate

CAS: 75567-37-2

Ref. BP-BP1635

Product Information

• Name: Ingenol Mebutate
• Synonyms: 3-Angeloyl Ingenol, 3-Angelyl Ingenol, 3-Ingenyl Angelate, Ingenyl 3-Angelate, Ingenol 3-Angelate, PEP005, 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecene, 2-butenoic acid deriv., 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-, 2-Butenoic acid, 2-methyl-, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, [1aR-[1aα,2β,5β,5aβ,6β(Z),8aα,9α,10aα]]-, 3-Angeloylingenol, Aids-416619, Aids416619, Euphorbia factor An₁, Euphorbia factor H₁, I3A, Ingenol 3-angelate, Ingenol 3-mebutate, Ingenol mebutate, Pep 005, Picato, Euphorbia factor An1

Description

Ingenol-3-angelate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of ingenol-3-angelate in vivo; it activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCdelta. Ingenol-3-angelate suppresses HIV infection of primary CD4+ T cells through down-modulation of cell surface expression of HIV co-receptors. Ingenol-3-angelate emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases.

• Brand: Biopurify

Chemical properties

• Molecular weight: 430.541
• Formula: C₂₅H₃₄O₆
• Purity: 95%~99%