Decursinol angelate

CAS: 130848-06-5

Ref. BP-BP1812

Product Information

• Name: Decursinol angelate
• Synonyms: Acutilobin, Decursinol mebutate, 2-Butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl ester, (2Z)-, 2-Butenoic acid, 2-methyl-, 7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl ester, [S-(Z)]-, 2-Butenoicacid, 2-methyl-, 7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-ylester, [S-(Z)]-, 2H,6H-Benzo[1,2-b:5,4-b']dipyran, 2-butenoic acid deriv.

Description

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. It improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast.

• Brand: Biopurify

Chemical properties

• Molecular weight: 328.364
• Formula: C₁₉H₂₀O₅
• Purity: 95%~99%
• InChI: InChI=1S/C19H20O5/c1-5-11(2)18(21)23-16-9-13-8-12-6-7-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/b11-5-/t16-/m0/s1
• InChI key: InChIKey=AGABNGOXUSXQDD-XKGFZTIGSA-N
• SMILES: C/C=C(/C)C(=O)O[C@H]1Cc2cc3ccc(=O)oc3cc2OC1(C)C