Marein

CAS: 535-96-6

Ref. BP-BP2136

Product Information

• Name: Marein
• Synonyms: Okanin 4'-O-β-D-Glucopyranoside, (2E)-3-(3,4-Dihydroxyphenyl)-1-[4-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one, (E)-3-(3,4-Dihydroxyphenyl)-1-(4-(beta-D-glucopyranosyloxy)-2,3-dihydroxyphenyl)-2-propen-1-one, 2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-(4-(beta-D-glucopyranosyloxy)-2,3-dihydroxyphenyl)-, (E)-, 2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[4-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-2,3-dihydroxyphenyl]-, (2E)-, 2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[4-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-2,3-dihydroxyphenyl]-, (E)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-2,3-dihydroxyphenyl beta-D-glucopyranoside, Chalcone, 2′,3,3′,4,4′-pentahydroxy-, 4′-β-<span class="text-smallcaps">D</span>-glucopyranoside, Glucopyranoside, okanin-4′, β-<span class="text-smallcaps">D</span>-, Okanin 4′-O-β-<span class="text-smallcaps">D</span>-Glucopyranoside, Okanin-4'-O-glucoside

Description

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. Marein can improve insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein shows antioxidant activity, it shows Histone deacetylase enzymes (HDACs) inhibitory activity and it also can inhibit TNFα-induced NF-κB activation.

• Brand: Biopurify

Chemical properties

• Molecular weight: 450.396
• Formula: C₂₁H₂₂O₁₁
• Purity: 95%~99%