Rosmanol

CAS: 80225-53-2

Ref. BP-BP3643

Product Information

• Name: Rosmanol
• Synonyms: (6beta,7alpha)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one, 2H-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10S,10aS)-, [4aR-(4aa,9b,10a,10ab)]-1,3,4,9,10,10a-Hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10,4a-(epoxymethano)phenanthren-12-one

Description

Rosmanol has antioxidant activity, it can activate the antioxidant response element, it also has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol exhibits significant cytotoxicity towards the neuroblastoma cells, it potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells.Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.

• Brand: Biopurify

Chemical properties

• Molecular weight: 344.451
• Formula: C₂₁H₂₈O₄
• Purity: 95%~99%
• InChI: InChI=1S/C21H28O4/c1-10(2)11-8-12-15(18(25)17(11)24)21-7-5-6-20(3,4)19(21)13(16(12)23)9-14(21)22/h8,10,13,16,19,23-25H,5-7,9H2,1-4H3/t13-,16+,19?,21+/m1/s1
• InChI key: InChIKey=ZPGPREPDSQALNB-BTWRULSLSA-N
• SMILES: CC(C)c1cc2c(c(O)c1O)[C@@]13CCCC(C)(C)C1[C@H](CC3=O)[C@H]2O