DAB2 rabbit pAb
Ref. EK-ES17027
50µl
188.00€
100µl
316.00€
Product Information
Name:DAB2 rabbit pAb
Synonyms:
- Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)
Brand:ELK Biotechnology
Description:This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
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Chemical properties
Technical inquiry about: DAB2 rabbit pAb
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