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Bestrophin-1 rabbit pAb

Ref. EK-ES20817

50µl
188.00€
100µl
316.00€
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ELK Biotechnology

Product Information

Name:Bestrophin-1 rabbit pAb
Synonyms:
  • Bestrophin-1 (TU15B;Vitelliform macular dystrophy protein 2)
Brand:ELK Biotechnology
Description:This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],
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