ER81 rabbit pAb
Ref. EK-ES2286
50µl
188.00€
100µl
316.00€
Product Information
Name:ER81 rabbit pAb
Synonyms:
- ETV1; ER81; ETS translocation variant 1; Ets-related protein 81
Brand:ELK Biotechnology
Description:This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alte
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Chemical properties
Technical inquiry about: ER81 rabbit pAb
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