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ErbB-3 (phospho Tyr1328) rabbit pAb

Ref. EK-ES5152

50µl
188.00 €
100µl
316.00 €
Estimated delivery in United States, on Friday 13 Dec 2024

Product Information

Name:
ErbB-3 (phospho Tyr1328) rabbit pAb
Synonyms:
  • ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
Description:

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
ELK Biotechnology
Long term storage:
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Hazard Info

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Forbidden to fly:
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