Cleaved-Factor XII HC (I20) rabbit pAb
Ref. EK-ES5190
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- F12; Coagulation factor XII; Hageman factor; HAF
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
Chemical properties
Technical inquiry about: EK-ES5190 Cleaved-Factor XII HC (I20) rabbit pAb
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