NARF rabbit pAb
Ref. EK-ES5498
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- NARF; Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It
Chemical properties
Technical inquiry about: EK-ES5498 NARF rabbit pAb
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