VHL rabbit pAb
Ref. EK-ES7499
50µl
188.00€
100µl
316.00€
Product Information
Name:VHL rabbit pAb
Synonyms:
- VHL; Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL
Brand:ELK Biotechnology
Description:von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
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Chemical properties
Technical inquiry about: VHL rabbit pAb
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