Neuregulin-3 rabbit pAb
Ref. EK-ES8415
50µl
188.00€
100µl
316.00€
Product Information
Name:Neuregulin-3 rabbit pAb
Synonyms:
- NRG3; Pro-neuregulin-3
- membrane-bound isoform; Pro-NRG3
Brand:ELK Biotechnology
Description:This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri
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