HLA-DMβ rabbit pAb
Ref. EK-ES8783
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- HLA class II histocompatibility antigen
- DM beta chain (MHC class II antigen DMB;Really interesting new gene 7 protein)
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
Chemical properties
Technical inquiry about: EK-ES8783 HLA-DMβ rabbit pAb
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