MRT67307
CAS: 1190378-57-4
Ref. TM-T0097
| 1mg | 40.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 235.00 € | ||
| 50mg | 451.00 € | ||
| 100mg | 643.00 € | ||
| 1ml*10 (DMSO) | 86.00 € |
Product Information
- MRT67307 HCl
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s =250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively).
Chemical properties
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