Ebselen

CAS: 60940-34-3

Ref. TM-T0825

Product Information

• Name: Ebselen
• Synonyms: SPI-1005, PZ-51, CCG-39161, 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-, 2-Phenyl-1,2-benzisoselenazol-3(2H)-one, 2-Phenyl-1,2-benzoisoselenazol-3(2H)-one, 2-Phenyl-1,2-benzoselenazol-3-one, 2-Phenylbenzo[d][1,2]selenazol-3(2H)-one, 2-phenyl-1,2-benzoselenazol-3(2H)-one, Ccg-39161, Dr 3305, Lopac E 3520, NSC 639762, Pz 51, Spi 1005
• CAS: 60940-34-3

Description

Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

• Brand: Targetmol

Chemical properties

• Molecular weight: 274.18
• Formula: C₁₃H₉NOSe
• Purity: 99.94%
• Color/Form: White Solid
• InChI: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
• InChI key: InChIKey=DYEFUKCXAQOFHX-UHFFFAOYSA-N
• SMILES: O=c1c2ccccc2[se]n1-c1ccccc1