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EN6
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EN6

CAS: 1808714-73-9

Ref. TM-T11191

1mg
46.00 €
5mg
87.00 €
10mg
134.00 €
25mg
202.00 €
50mg
259.00 €
100mg
392.00 €
500mg
889.00 €
1ml*10 (DMSO)
69.00 €
Estimated delivery in United States, on Thursday 9 May 2024

Product Information

Name:
EN6
Synonyms:
  • EN-6
Description:

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

Brand:
Targetmol
Long term storage:
Notes:

Chemical properties

Molecular weight:
368.34
Formula:
C19H14F2N4O2
Purity:
97.04%
Color/Form:
Solid
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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