EN6
CAS: 1808714-73-9
Ref. TM-T11191
1mg | 46.00 € | ||
5mg | 87.00 € | ||
10mg | 134.00 € | ||
25mg | 202.00 € | ||
50mg | 259.00 € | ||
100mg | 392.00 € | ||
500mg | 889.00 € | ||
1ml*10 (DMSO) | 69.00 € |
Product Information
- EN-6
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
Chemical properties
Technical inquiry about: TM-T11191 EN6
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