Product Information
- MK 966, MK-0966
- 2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-
- 3-(4-Methanesulfonylphenyl)-2-phenyl-2-buten-4-olide
- 3-Phenyl-4-[4-(Methylsulfonyl)phenyl]-2(5H)-furanone
- 4-(4-(Methanesulfonyl)phenyl)-3-phenyl-5H-furan-2-one
- 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone
- 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
- Ceeoxx
- Ceoxx
- Mk 0966
- See more synonyms
- Mk 966
- Rhuma-cure
- Romacox
- Vioxx
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
Chemical properties
Technical inquiry about: TM-T1185 Rofecoxib
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