SAR405
CAS: 1523406-39-4
Ref. TM-T12831L
| 1mg | 52.00 € | ||
| 2mg | 78.00 € | ||
| 5mg | 102.00 € | ||
| 10mg | 177.00 € | ||
| 25mg | 351.00 € | ||
| 50mg | 541.00 € | ||
| 1ml*10 (DMSO) | 95.00 € |
Estimated delivery in United States, on Friday 17 May 2024
Product Information
Name:
SAR405
Synonyms:
- SAR-405
CAS:
Description:
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
Brand:
Targetmol
Long term storage:
Notes:
Chemical properties
Molecular weight:
443.85
Formula:
C19H21ClF3N5O2
Purity:
99.79%
Color/Form:
Solid
InChI:
InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1
InChI key:
InChIKey=SPDQRCUBFSRAFI-DOMZBBRYSA-N
SMILES:
C[C@@H]1COCCN1c1cc(=O)n2c(n1)N(Cc1cncc(Cl)c1)[C@H](C(F)(F)F)CC2
MDL:
Melting point:
Boiling point:
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Density:
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EINECS:
Merck:
HS code:
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