AMG-1694
CAS: 1361217-07-3
Ref. TM-T14212
| 1mg | 353.00 € | ||
| 5mg | 822.00 € | ||
| 10mg | 1,138.00 € | ||
| 25mg | 1,633.00 € | ||
| 50mg | 2,032.00 € | ||
| 100mg | 2,616.00 € |
Product Information
AMG-1694, a potent disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.
Chemical properties
Technical inquiry about: TM-T14212 AMG-1694
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