CBR-5884
CAS: 681159-27-3
Ref. TM-T14884
2mg | 46.00 € | ||
5mg | 68.00 € | ||
10mg | 94.00 € | ||
25mg | 212.00 € | ||
50mg | 367.00 € | ||
100mg | 550.00 € | ||
1ml*10 (DMSO) | 74.00 € |
Product Information
- CBR5884
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
Chemical properties
Technical inquiry about: TM-T14884 CBR-5884
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