Clobetasol propionate

CAS: 25122-46-7

Ref. TM-T1561

Product Information

• Name: Clobetasol propionate
• Synonyms: Dermovate, Clobetasol 17-propionate, CGP9555, Temovate, CCl 4725, (11Beta,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate, (11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, (8Xi,11Beta,14Xi,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate, 17-Propionate De 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione, 17-Propionato De 21-Cloro-9-Fluoro-11Β,17-Dihidroxi-16Β-Metilpregna-1,4-Dieno-3,20-Diona, 21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat, 21-Chloro-21-deoxybetamethasone 17-propionate, 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate, CCl 4725, Cgp 9555, Clobederm, Clobesol, Clobetasol 17-propionate, Clobetasole Propionate, Clobetazol Propiorate, Clobex, Dermoval, Dermovate, Dermoxin, Dermoxinale, Gr 2/925, Karison, Olux-E, Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-, Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate, Skin Cap, Temovate, Tenovate
• CAS: 25122-46-7

Description

Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

• Brand: Targetmol

Chemical properties

• Molecular weight: 466.97
• Formula: C₂₅H₃₂ClFO₅
• Purity: 98.44%
• Color/Form: White Crystalline Powder