hURAT1 inhibitor 1
Ref. TM-T200163
Product Information
Name:hURAT1 inhibitor 1
Brand:Targetmol
Description:Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.
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Chemical properties
Molecular weight:451.31
Formula:C24H19BrO4
Technical inquiry about: hURAT1 inhibitor 1
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