Product Information
Name:PQA-18
Synonyms:
- Prenylated Quinolinecarboxylic Acid Compound-18
Brand:Targetmol
Description:PQA-18, an inhibitor of p21-activated kinase 2 (PAK2; IC50 = 10 nM), is derived from Ppc-1 (product number 42352) and exhibits immunosuppressive properties. It inhibits IL-2 production in Jurkat T cells induced by Concanavalin A (product number 14951) with an IC50 of 400 nM. Topically applied at 0.1%, PQA-18 reduces the severity of atopic dermatitis, serum IgE levels, and skin thickness in the NC/Nga mouse model. A lower concentration of 0.05% also decreases skin nerve fiber density in NC/Nga mice. Additionally, PQA-18 administered at 4 mg/kg improves graft survival in a rat small intestine transplantation model.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:409.52
Formula:C25H31NO4
Color/Form:Solid
Technical inquiry about: PQA-18
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