PDL1 degrader-2
Ref. TM-T201649
10mg
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50mg
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Product Information
Name:PDL1 degrader-2
Brand:Targetmol
Description:PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:780.91
Formula:C45H48N8O5
Color/Form:Solid
Technical inquiry about: PDL1 degrader-2
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