ROCK/HDAC-IN-1
Ref. TM-T201708
Product Information
Name:ROCK/HDAC-IN-1
Brand:Targetmol
Description:ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:386.47
Formula:C19H22N4O3S
Color/Form:Solid
Technical inquiry about: ROCK/HDAC-IN-1
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