Product Information
Name:O-Desmethylcarvedilol
Synonyms:
- Desmethylcarvedilol
- BM-14242
Brand:Targetmol
Description:O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 µM). Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:392.45
Formula:C23H24N2O4
Color/Form:Solid
Technical inquiry about: O-Desmethylcarvedilol
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