Product Information
Name:(rac)-Talazoparib
Synonyms:
- (rac)-LT-673
- (rac)-BMN-673
Brand:Targetmol
Description:(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.
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Chemical properties
Molecular weight:380.351
Formula:C19H14F2N6O
Color/Form:Solid
Technical inquiry about: (rac)-Talazoparib
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