WR-S-462
Ref. TM-T205090
Product Information
Name:WR-S-462
Brand:Targetmol
Description:WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:462.52
Formula:C24H22N4O4S
Color/Form:Solid
Technical inquiry about: WR-S-462
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