SJ44236
Ref. TM-T205126
Product Information
Name:SJ44236
Brand:Targetmol
Description:SJ44236 is a BET PROTAC degrader capable of degrading BRD2 (DC50 = 0.127 nM), BRD3, and BRD4. It shows cytotoxicity in MV4-11 and HD-MB03 cells with IC50 values of 0.12 nM and 0.92 nM, respectively. The compound downregulates c-Myc expression and upregulates p53 expression. In mice, SJ44236 demonstrates good oral bioavailability (45%). [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonE3ligaseLigand 54]
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:753.36
Formula:C40H45ClN8O3S
Color/Form:Solid
Technical inquiry about: SJ44236
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