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KKL-40

CAS:

Ref. TM-T205229

KKL-40
Targetmol

Product Information

Name:KKL-40
Brand:Targetmol
Description:KKL-40 is a small-molecule inhibitor that targets the trans-translation process, effectively suppressing methicillin-sensitive and resistant Staphylococcus aureus (S. aureus) and other Gram-positive pathogens, including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. It works in synergy with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not show synergistic effects with other antibiotics such as daptomycin, kanamycin, or erythromycin. KKL-40 inhibits trans-translation, an extreme form of recoding, while being non-toxic to HeLa cells.
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Chemical properties

Molecular weight:351.255
Formula:C16H9F4N3O2
Color/Form:Solid

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