CQ1373
Ref. TM-T205249
Product Information
Name:CQ1373
Brand:Targetmol
Description:CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:546.93
Formula:C25H22ClF3N6O3
Color/Form:Solid
Technical inquiry about: CQ1373
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