VISTA-IN-4
Ref. TM-T205442
Product Information
Name:VISTA-IN-4
Brand:Targetmol
Description:VISTA-IN-4 (Compound B3) is an orally active inhibitor of the immune checkpoint protein VISTA, with a KD of 0.452 μM. It degrades VISTA in HepG2 cells with a degradation rate of 77% at a concentration of 5 μM. VISTA-IN-4 counteracts VISTA-mediated immune suppression, restoring T cell activity and promoting the release of cytokine IL-2. Additionally, it exhibits antitumor activity in CT26 xenograft mouse models and demonstrates favorable pharmacokinetic properties, with good oral serum exposure in SD rats, reflected by an AUC(0-t) of 412.9 mg·h/mL.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:388.48
Formula:C24H25FN4
Color/Form:Solid
Technical inquiry about: VISTA-IN-4
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