Nurr1 agonist 12
Ref. TM-T206188
Product Information
Name:Nurr1 agonist 12
Brand:Targetmol
Description:Nurr1 agonist 12 (Compound 37) acts as an agonist of the nuclear receptor-related protein 1 (Nurr1), enhancing its transcriptional activity with an EC50 of 0.06 μM. It stimulates human response elements NBRE, NurRE, and DR5 with EC50 values of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Additionally, Nurr1 agonist 12 induces the expression of neurotrophic genes regulated by Nurr1, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). The compound also demonstrates neuroprotective effects against neurotoxicity caused by Paraquat.
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Chemical properties
Molecular weight:321.76
Formula:C18H12ClN3O
Color/Form:Solid
Technical inquiry about: Nurr1 agonist 12
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