Product Information
Name:β-Glucuronidase-IN-3
Brand:Targetmol
Description:β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric inhibitor targeting β-glucuronidase. It exhibits potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) with an IC50 of 12.9 nM. The compound exerts its inhibitory effect through reversible covalent modification of cysteine residues (Cys28, Cys443, and Cys197) on EcGUS. It is applicable in research on gut microbiota-related diseases, particularly in reducing the toxic side effects of Irinotecan and non-steroidal anti-inflammatory drugs (NSAIDs).
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Chemical properties
Molecular weight:264.14
Formula:C10H7N3OSe
Color/Form:Solid
Technical inquiry about: β-Glucuronidase-IN-3
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