Product Information
Name:HLDA-212
Brand:Targetmol
Description:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1478.47
Formula:C70H90BrFN8O19S
Technical inquiry about: HLDA-212
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