Product Information
Name:PDEδ/NAMPT IN-1
Brand:Targetmol
Description:PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.
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Chemical properties
Molecular weight:494.61
Formula:C26H30N4O4S
Color/Form:Solid
Technical inquiry about: PDEδ/NAMPT IN-1
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