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PR280

Ref. TM-T210078

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Targetmol

Product Information

Name:PR280
Brand:Targetmol
Description:PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) with an IC50 of 700 nM. It forms hydrogen bonds with amino acid residues of Des1, while its cyclopropenone group may coordinate with the iron center, stabilizing its binding at Des1's active site. This inhibits the ceramide biosynthesis pathway, preventing dihydroceramide (dhCer) from converting into ceramide. PR280 can be used in research related to sphingolipid metabolism disorders, including cancer and metabolic diseases.
Notice:Our products are intended for lab use only. For any other use, please contact us.

Chemical properties

Molecular weight:451.36616
Formula:C27H49NO4

Technical inquiry about: PR280

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