Trivalent GalNAc-DBCO

CAS: 2765060-22-6

Ref. TM-T210528

Product Information

• Name: Trivalent GalNAc-DBCO
• Brand: Targetmol
• Description: Trivalent GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Trivalent GalNAc-DBCO undergoes strain-promoted alkyne–azide cycloaddition (SPAAC) reactions with azide-containing molecules without the need for copper catalysis. Trivalent GalNAc-DBCO binds specifically to the asialoglycoprotein receptor (ASGPR), thereby directing conjugated molecules into hepatocytes for lysosomal degradation through receptor-mediated endocytosis. Trivalent GalNAc-DBCO is extensively applied in studies of liver-targeted drug delivery, targeted degradation strategies, and hepatocyte-specific molecular engineering.

Chemical properties

• Molecular weight: 1950.18
• Formula: C₉₁H₁₄₄N₁₂O₃₄
• Purity: 96.33%