c-MYC/BCL2 ligand 1 iodide
Ref. TM-T211076
10mg
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50mg
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Product Information
Name:c-MYC/BCL2 ligand 1 iodide
Brand:Targetmol
Description:c-MYC/BCL2 ligand 1 iodide is a dual-target ligand that specifically interacts with the G-quadruplex (G4) regions of the c-MYC and Bcl-2 promoters, exhibiting Kd values of 0.90 μM for c-MYCG4 and 0.56 μM for Bcl-2G4. It works by binding to these G4-forming sequences to inhibit transcription of the c-MYC and Bcl-2 genes, leading to reduced protein expression. This compound effectively suppresses MCF-7 cell proliferation and migration, induces G1 phase cell cycle arrest, and triggers apoptosis. Additionally, it significantly hampers tumor growth in the 4T1 homogenous model with negligible toxicity. c-MYC/BCL2 ligand 1 iodide is applicable in breast cancer research.
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Chemical properties
Color/Form:Odour Solid
Technical inquiry about: c-MYC/BCL2 ligand 1 iodide
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