Product Information
Name:PVTX-405
Brand:Targetmol
Description:PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:525.60
Formula:C30H31N5O4
Color/Form:Solid
Technical inquiry about: PVTX-405
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