AurAP14
Ref. TM-T215239
Product Information
Name:AurAP14
Brand:Targetmol
Description:AurAP14 is an Aurora APROTAC degrader with a DC50 of 120 nM. It exhibits notable inhibitory activity against various tumor cell lines, with an IC50 of 0.294 μM in A549 cells and 0.534 μM in MCF-7 cells. AurAP14 induces apoptosis in A549 cells and causes cell cycle arrest in the S and G2/M phases. It demonstrates antitumor efficacy in both A549 and A549/PTR nude mouse xenograft models. AurAP14 is applicable for studying treatments for non-small cell lung cancer (NSCLC) with Aurora A overexpression.
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Chemical properties
Technical inquiry about: AurAP14
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