Product Information
Name:FXR DUBTAC IN-1
Brand:Targetmol
Description:FXRDUBTAC IN-1 (compound D11) is a deubiquitinase-targeting chimera (DUBTAC) designed to target FXR, with a Ka value of 2.12e-5 M. This compound recruits the deubiquitinase OTUB1 to form a ternary complex with FXR, reducing FXR's polyubiquitination levels. It prevents FXR degradation via the ubiquitin-proteasome pathway, thereby increasing FXR protein levels. FXRDUBTAC IN-1 is used in the study of cholestatic liver injury.
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Chemical properties
Molecular weight:751.01
Formula:C43H66N4O7
Technical inquiry about: FXR DUBTAC IN-1
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