COH29
CAS: 1190932-38-7
Ref. TM-T3157
1mg | 37.00 € | ||
2mg | 52.00 € | ||
5mg | 78.00 € | ||
10mg | 118.00 € | ||
25mg | 213.00 € | ||
50mg | 348.00 € | ||
100mg | 578.00 € | ||
1ml*10 (DMSO) | 85.00 € |
Product Information
- RNR Inhibitor COH29
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR inhibitor COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail. Inhibition of RNR activity decreases the pool of deoxyribonucleotide triphosphates available for DNA synthesis. The resulting decrease in DNA synthesis causes cell cycle arrest and growth inhibition. In addition, this agent may inhibit the nuclear enzyme poly (ADP-ribose) polymerase (PARP) 1, which prevents the repair of damaged DNA and causes both the accumulation of single and double strand DNA breaks and the induction of apoptosis.
Chemical properties
Technical inquiry about: TM-T3157 COH29
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.