A-366

CAS: 1527503-11-2

Ref. TM-T3624

Product Information

• Name: A-366
• Synonyms: A 366, A366
• CAS: 1527503-11-2

Description

A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.

• Brand: Targetmol

Chemical properties

• Molecular weight: 329.44
• Formula: C₁₉H₂₇N₃O₂
• Purity: 99.8%
• Color/Form: Solid
• InChI: InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
• InChI key: InChIKey=BKCDJTRMYWSXMC-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1