Wortmannin

CAS: 19545-26-7

Ref. TM-T6283

Product Information

• Name: Wortmannin
• Synonyms: SL-2052, KY-12420, (1R,6bS,9aR,11S,11bS)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate, (1S,6Br,9As,11R,11Br) 11-(Acetyloxy)-1,6B,7,8,9A,10,11,11B-Octahydro-1-(Methoxymethyl)-9A,11B-Dimethyl-3H-Furo[4,3,2-De]Indeno[[4,5-H]-2-H]-2-Benzopyran-3,6,9-Trione, (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate, (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, (1S,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate, 1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate, 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-, 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, [1S-(1α,6bα,9aβ,11α,11bβ)]-, Antibioticsl-2052, Ky 12420, Pi 3-Kinase Inhibitor, Sl-2052, Wortmannin, Penicillium Wortmanni, [1S-(1Alpha,6Balpha,9Abeta,11Alpha,11Bbeta)]-11-(Acetyloxy)-1,6B,7,8,9A,10,11,11B-Octahydro-1-(Methoxymethyl)-9A,11B-Dimethyl-3H-Furo[4,3,2-De]Indeno[4,5-H]-2-Benzopyran-3,6,9-Trione
• CAS: 19545-26-7

Description

Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.

• Brand: Targetmol

Chemical properties

• Molecular weight: 428.43
• Formula: C₂₃H₂₄O₈
• Purity: 99.76%
• Color/Form: White Solid
• InChI: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
• InChI key: InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N
• SMILES: COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O