Clevudine
CAS: 163252-36-6
Ref. TM-T6446
5mg | 51.00 € | ||
10mg | 78.00 € | ||
25mg | 123.00 € | ||
50mg | 193.00 € | ||
100mg | 344.00 € | ||
1ml*10 (DMSO) | 87.00 € |
Product Information
- L-FMAU, Levovir
- 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
- 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil
- 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-
- 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-
- L-Fmau
- Levovir
- See more synonyms
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
Chemical properties
Technical inquiry about: TM-T6446 Clevudine
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