2-Bromo-4'-hydroxyacetophenone

CAS: 2491-38-5

Ref. TM-T7084

Product Information

• Name: 2-Bromo-4'-hydroxyacetophenone
• Synonyms: SHP-1 Inhibitor II, PTP Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl bromide, 1-(4-Hydroxyphenyl)-2-bromoethanone, 2-Bromo-1-(4-Hydroxyphenyl)Ethanone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one, 2-Bromo-4'-Hydroxy Acetophenone, 2-Bromo-4'-Hydroxyacetophenone, 4-Hydroxyphenacyl bromide, 4′-Hydroxy-2-bromoacetophenone, Acetophenone, 2-bromo-4′-hydroxy-, Busan 1130, Busan 90, Butrol 1130, Ethanone, 2-bromo-1-(4-hydroxyphenyl)-, p-Hydroxyphenacyl bromide, Α-Bromo-Hydroxyacetophenone, α-Bromo-1-(4-hydroxyphenyl)-ethanone, α-Bromo-4-Hydroxy Acetophenone, α-Bromo-4′-hydroxyacetophenone, α-Bromo-p-hydroxyacetophenone, ω-Bromo-p-hydroxyacetophenone
• CAS: 2491-38-5

Description

2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].

• Brand: Targetmol

Chemical properties

• Molecular weight: 215.04
• Formula: C₈H₇BrO₂
• Purity: 99.07%
• Color/Form: Clear Colorless To Light Yellow Liquid