Estimated delivery in United States, on Thursday 16 May 2024
Product Information
Name:
Irpagratinib
Synonyms:
- ABSK011
CAS:
Description:
Irpagratinib (ABSK011) is an orally active fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor with specificity for FGFR4, exhibiting an IC50 of less than 10 nM. It effectively inhibits FGFR4 auto-phosphorylation and disrupts subsequent signal transduction to downstream pathways. Demonstrating high exposure in pharmacokinetic studies in mice, rats, and dogs, Irpagratinib also displays antineoplastic activity in subcutaneous xenograft tumor models [1].
Brand:
Targetmol
Long term storage:
Notes:
Chemical properties
Molecular weight:
570.59
Formula:
C28H32F2N6O5
Purity:
98%
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: TM-T79850 Irpagratinib
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